Born in La Laguna in 1906, the life of this universal artist was defined by various events that tormented him and are portrayed in his work. Overprotected by his grandmother and sisters after his mother's death, Domínguez was a mischievous and somewhat destructive child. For much of his life he suffered acromegaly, causing his head to grow in an abnormal manner. He travelled to Paris at the age of 26 to tend to his father's business. It was there that he met André Breton, Dalí, Picasso and Miró, and where he delved into the surrealism of the city's exhibitions and art schools. He invented the decalcomania technique, which consisted of staining paper with ink, placing another sheet over it and creating art based on the random shapes that formed. His work features counterposed elements, the transformation of certain objects into others, deformed faces and other somewhat provocative content. Troubled by his failure to achieve his own style, Domínguez chose to end his life on 31 December 1957 in Paris.
His most prominent work includes The Infernal Machine, La Media, El Caballo de Troya, Le Taureau and Le Piano, in addition to his self-portraits.
The Tenerife Art Space houses the Óscar Domínguez Institute which is dedicated to the life and work of this and a number of other 20th and 21st century local, national and international artists. One of the exhibition halls displays a variety of his art work.